Jeremy Chambers

Education

• Postdoctoral Associate, Molecular Therapeutics, The Scripps Research Institute, Florida
• Postdoctoral Associate, Department of Cancer Biology, University of Pennsylvania
• Ph.D. Biochemistry, Clemson University
• Bachelor of Science, West Liberty University

Research Interests

Organophosphates

Neurotoxicology

Drug & Diagnostic Development

Mitochondria

Signal Transduction

Patents

Recent Publications

For a complete list of Dr. Chambers’ publications, please visit: https://www.ncbi.nlm.nih.gov/myncbi/1z3h3p8bO3RkS/bibliography/public/

1. Bales, BC, Cotero, V, Roberts, JC, Rodriguez-Silva, M, Siclovan, TM, Chambers, JW, and Rishel, MJ. A Novel Aminopyrazole as an Isoform-Selective Probe for Active JNK3 Quantitation in the Brain. ACS Med. Chem. Lett. (2022). 13(10). 1606-1614. PMID:36262398.
2. Alfonso, EE, Deng, Z, Boaretto, D, Hood, B, Vasile, S, Smith, LH, Chambers, JW, Chapagain, P, and Leng, F. Novel and Structurally Diversified Bacterial DNA Gyrase Inhibitors Discovered through a Fluorescence-Based High-Throughput Screening Assay. ACS Pharmacol. Transl. Sci. (2022). 5(10). 932-944. PMID: 36268121.
3. Azmoun, S, Diaz, Y, Tang, CY, Horton, M, Clouston, SAP, Luft, BJ, Bromet, EJ, Gandy, S, Placidi, D, Ambrosi, C, Mascaro, L, Rodella, C, Paghera, B, Gasparotti, R, Chambers, JW, Tieu, K, Lucchini, RG. Cognitive impact of exposure to airborne particles captured by brain imaging. Adv. Neurotoxicol. Volume 7. (2022). DOI: 10.1016/bs.ant.2022.05.002.
4. Balachandar L, Montejo KA, Castano E, Perez M, Moncion C, Chambers JW, Lujan JL, Riera Diaz J. Simultaneous Ca²⁺ imaging and optogenetic stimulation of cortical astrocytes in adult murine brain slices. Curr. Prot. Neurosci. (2020). 94(1). PMID: 33285041
5. Su L, Bryan N, Battista S, Freitas J, Garabedian A, D’Alessio F, Romano M, Falanga F, Fusco A, Kos L, Chambers J, Fernandez-Lima F, Chapagain PP, Vasile S, Smith L, and Leng F. Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci. Rep. (2020). 10(1). PMID: 33139812
6. Citron-Diaz, YL, Acanda de la Rocha, AM, Castellanos, A, Chambers, JW, and Fernandez-Lima, F. Mapping chemotherapeutic drug distribution in cancer cell spheroids using 2D-TOF-SIMS and LESA-TIMS-MS. Analyst. (2020). 145(21). 7056-7062. PMID: 32966375.
7. Loth, MK, Guariglia, SR, Re DB, Perez, J, Nunes de Paiva, V, Dziedzic, JL, Chambers, JW, Azzam, DJ, and Guilarte, TR. A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in Microglia. Mol Neurobiol. (2020). 57(11). 4467-4487. PMID: 32743737.
8. Rodriguez-Silva, M, Ashourian, KT, Smith, AD, and Chambers JW. Assessment of Mitochondrial Stress in Neurons: Proximity Ligation Assays to Detect Recruitment of Stress-Responsive Proteins to Mitochondria. Neuromethods: Cell Culture Techniques. (2019). DOI: 10.1007/978-1-4939-9228-7_6
9. Wang, W, Rodriguez-Silva, M, Acanda De La Rocha, A, Wolf, A, Lai Y, Liu, Y, Reinhold, W, Pommier, Y, Chambers, JW*, and Tse-Dinh, Y. Tyrosyl-DNA phosphodiesterase 1 and topoisomerase 1 activities as predictive indicators for glioblastoma susceptibility to genotoxic agents. Cancers (Basel). 11(10). (2019). PMID: 31547492. *co-corresponding author.
10. Lucero, M, Suarez, AE and Chambers, JW. Phosphoregulation on mitochondria: integration of cell and organelle responses. CNS Neurosci Ther. (2019). 00: 1–22. https://doi.org/10.1111/cns.13141. PMID: 31025544.
11. Sodero, AO, Rodriguez-Silva, M, Sailo, C, Sassoe-Pognetto, M and Chambers, JW. Sab is differentially expressed in the brain and affects neuronal activity. Brain Res. 1670. (2017). 76-85. PMID: 28606781.

Current Funding

As Principal Investigator

Chambers, PI              NIH/NIEHS                R21ES032597                           09/01/21-08/31/23

Acetylcholinesterase Complex Protein-Protein Interactions as Drug Targets Against Organophosphate-induced Neurotoxicity.

As  a Co-Investigator

Guilarte, PI   NIH/NIEHS                                R01ES007062                                  09/19/19-05/31/24

Peripheral BDZ Receptor – Biomarker of Neurotoxicity.