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Deodutta Roy

Professor

Environmental Health Sciences


Focus

Stem Cell Aging and Cancer, Mitochondrial Dysfunction and Neurological Diseases

Biography

Dr. Deodutta Roy joined Florida International University (FIU) as a professor in 2004 and was the founding chairman of the Department of Environmental and Occupational Health from 2005-2011. Before joining FlU, he was a tenured professor at the University of Alabama at Birmingham from 1998-2004. Nationally and internationally recognized in the estrogen carcinogenesis field, Dr. Roy has received several awards and honors for his research work, including Junior Faculty Development Award from American Cancer Society and Scholar Awards in cancer research from the American Association for Cancer Research (AACR).

Dr. Roy is a prolific scholar and researcher, having published over one hundred peer-reviewed articles, book chapters, monographs, and two patents. He has trained 15 doctoral students and numerous postdoctoral fellows. For the last 24 years, his research program has been continuously funded through grants from the American Cancer Society, U.S. National Institutes of Health, the Department of Defense, and Veteran Affairs. Dr. Roy has served on a variety of research-related advisory boards and review panels, including National Institutes of Health, the Susan Komen Foundation, Miami VA, and the Massachusetts Public Health Breast Cancer review panels. Dr. Roy is also on the editorial boards of nine scientific journals. He has collaborated with scientists at Miami Children’s Hospital, University of Miami, and Miami Veterans Affairs Healthcare System to investigate human DNA variants, epigenetic, stochastic and environmental factors that modify responses to exposure to endocrine disrupting stressors.

Lab

Environmental Functional Genomics (Application of Human Genomics/Epigenomics to Population Sciences: Molecular Prevention): The Environmental Functional Genomics Group has been engaged in characterizing underlying genetic, epigenetic and environmental factors that contribute to variability in human responses to endocrine disrupting stressors. We especially focus on discovery of epigenetic, stochastic and environmental factors that modify responses to exposure to endocrine disrupting stressors and how these factors affect the susceptibility to complex chronic diseases, such as cancer, neurodegenerative lesions in exposed people. This information may prove useful in developing therapeutic targets for the molecular prevention and treatment of complex chronic diseases and discovery of valuable novel biomarkers for identifying at-risk individuals and devising chronic human disease-molecular prevention strategies.

Education

  • Baylor College of Medicine, Postdoctoral Fellow
  • University of Texas Medical Branch, Postdoctoral Fellow
  • Jawaharlal Nehru University, M.Phil., Ph.D
  • Bihar University, BS, MS
  • Rajendra College, BS

Publications/Research

Morgan M, Deoraj A, Felty Q, Roy D. Environmental estrogen-like endocrine disrupting chemicals and breast cancer. Mol Cell Endocrinol. 2016 Oct 4. pii: S0303-7207(16)30411-7.

Preciados M, Yoo C, Roy D. Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases. Int J Mol Sci. 2016 Dec 13;17(12). pii: E2086

Victor Okoh, Nana Garba, Rosalind Penney, Jayanta Das, Alok Deoraj, Kamaleshwar Singh, Subhashish Sarkar, Quentin Felty, Changwon Yoo, Robert Jackson, and Deodutta Roy (2015) Redox signaling to nuclear regulatory proteins by reactive oxygen species contributes to estrogen-induced growth of breast cancer cells, British J Cancer,112(10):1687-702.

Brenda Luna, Sanjiv Bhatia, Changwon Yoo, Quentin Felty, David I. Sandberg, Michael Duchowny, Ziad Khatib, Ian Miller, John Ragheb, Jayakar Prasanna, Deodutta Roy (2014) Proteomic and mitochondrial genomic analyses of pediatric brain tumors. Mol Neurobiol 30 (11) 1-23

Brenda Luna, Sanjiv Bhatia, Changwon Yoo, Quentin Felty, David I. Sandberg, Michael Duchowny, Ziad Khatib, Ian Miller, John Ragheb, Jayakar Prasanna, Deodutta Roy (2014) Bayesian network and mechanistic hierarchical structure modeling of increased likelihood of developing intractable childhood epilepsy from the combined effect of mtDNA variants, oxidative damage, and copy number. J Mol Neurosci 54(4):752-766