Terrilyn A. Richardson

TITLE

Clinical Associate Professor

Environmental Health Sciences

CONTACT

terichar@fiu.edu

FOCUS

Toxicology, Pharmacology

Hepatic metabolism of xenobiotics

BIOGRAPHY

Prior to joining Florida International University, Dr. Richardson worked for approximately 10 years in the pharmaceutical industry, developing both biologic and small molecule pharmaceuticals in oncology and cardiovascular disease. She gained extensive experience in the design, oversight, and interpretation of toxicology and pharmacology studies intended to support Investigational New Drugs (INDs) and designed and interpreted data needed for ongoing product development. In addition, Dr. Richardson coordinated and monitored outsourced preclinical safety studies with contract research organizations. Dr. Richardson also has experience in strategy development, review and implementation of promotional material for marketed drugs and delivery devices for FDA compliance. During her graduate and post-doctoral research positions, Dr. Richardson investigated metabolism of organophosphate insecticides in developing animals, metabolism during thyroid tumor promotion, and investigation of hepatic enzymes and nuclear receptors during inflammation and infection.

EDUCATION

Emory University, Postdoctoral Fellow, Atlanta GA, 2003

University of Kansas Medical Center, Postdoctoral Fellow, Kansas City KS, 2001

Mississippi State University, Ph.D., Environmental Toxicology/Veterinary Medical Sciences, 2001

Mississippi State University, M.S., Animal Physiology, 1995

Mississippi State University, B.S., Biological Sciences, 1992

PUBLICATIONS

Schadt HS, Wolf A, Mahl JA, Wuersch K, Couttet P, Schwald M, Fischer A, Lienard M, Emote C, Teng CH, Skuba E, Richardson TA, Manenti L, Weiss A, Porta DG, Fairhurst RA, Kullak-Ublick GA, Chibout SD, Pognan F, Kluwe W, and Kinyamu-Akunda, J (2018). Bile acid sequestration by cholestyramine mitigates FGFR4 inhibition-Induced ALT-elevation. Toxicol Sci. 2018 May 1;163(1):265-278.

Roman D, VerHoeve, J, Schadt H, Vicart A, Junker Walker U, Turner O, Richardson TA, Wolford ST, Miller P, Zhou W, Lu H, Akimov M and Kluwe W (2016). Ocular toxicity of AUY922 in pigmented and albino rats. Toxicol Appl Pharmacol 309: 55-62.

Richardson TA and Klaassen CD (2010). Disruption of thyroid hormone homeostasis in UGTIA- deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation. Toxicol Appl Pharmacol 248(1): 38-44.

Richardson TA and Klaassen CD (2010). Role of UDP-Glucuronosyltransferase (UGT) 2B2 in metabolism of triiodothyronine: Effect of microsomal enzyme inducers in Sprague Dawley and UGT2B2- deficient Fischer 344 rats. Toxicol. Sci. 116(2): 413-421.

Chaluvadi MR, Kinloch RA, Nyagode BA, Richardson TA, Raynor MJ, Sherman M, Antonovic L, Strobel HW, Dillehay DL, and Morgan ET (2009). Regulation of hepatic cytochrome P450 expression in mice with intestinal or systemic infections of Citrobacter rodentium. Drug Metab Dispos 37: 366-374.

Zhang J, Chaluvadi MR, Reddy R, Motika MS, Richardson TA, Cashman JR, and Morgan ET (2009). Hepatic flavin-containing monooxygenase gene regulation in different mouse inflammation models.  Drug Metab Dispos 37: 462-468.

Morgan ET, Goralski KB, Piquette-Miller M, Renton KW, Robertson GR, Chaluvadi MR, Charles KA, Clarke SJ, Kacevska M, Liddle C, Richardson TA, Sharma R, and Sinal CJ (2008). Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer. Drug Metab Dispos 36(2):205-16.

Chen C, Shah YM, Morimura K, Krausz KW, Miyazaki M, Richardson TA, Morgan ET, Ntambi JM, Idle JR, and Gonzalez FJ (2008). Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell Metab 7(2):135-47.

Stienstra R, Mandard S, Tan NS, Wahli W, Trautwein C, Richardson TA, Lichtenauer-Kaligis E, Kersten S, and Müller M (2007). The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. J Hepatol 46(5):869-77.

Aitken AE*, Richardson TA*, and Morgan ET (2006). Regulation of drug metabolizing enzymes and transporters in inflammation. Ann Rev Pharmacol Toxicol 46:123-149. (*denotes equal contribution)

Richardson TA, Sherman M, Kalman D, and Morgan ET (2006). Regulation of UDP- glucuronosyltransferase isoforms during inflammation and infection in mouse liver and kidney. Drug Metab Disp 34(3):351-3.

Richardson TA, Sherman M, Antonovic L, Kardar SS, Strobel HW, Kalman D, and Morgan ET (2006). Hepatic and renal cytochrome P450 gene regulation during Citrobacter rodentium infection in wildtype and toll like receptor 4 (TLR4) mutant mice.  Drug Metab Disp 34(3):354-60.

Richardson TA and Morgan ET (2005). Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice. J Pharmacol Exp Ther 314:703-709.

Carr RL, Richardson JR, Guarisco JA, Kachroo A, Chambers JE, Couch TA, Durunna GC and Meek EC (2002).  Effects of PCB exposure on the toxic impact of organophosphorus insecticides. Toxicol Sci 67(2): 311-21.

Carr RL, Couch TA, Liu J, Coats JR and Chambers JE (1999). The interaction of chlorinated alicyclic insecticides with brain GABAA receptors in channel catfish (Ictalurus punctatus). J Toxicol Env Health Part A 56:543-554.

Atterberry TT, Burnett WT, and Chambers JE (1997). Age-related differences in parathion and chlorpyrifos toxicity in male rats: Target and nontarget esterase sensitivity and cytochrome P450- mediated metabolism.  Toxicol Appl Pharmacol 147:411-418.