Jennifer McGlothan Dziedzic
Focus
Neurotoxicology
Biography
Ms. Dziedzic graduated from Salisbury University in 1996 with a bachelor’s degree in Biology, along with a minor in Chemistry. After graduation, she joined the laboratory of Tomás R. Guilarte, PhD in the Department of Environmental Health Sciences at Johns Hopkins University Bloomberg School of Public Health as a research technician. While continuing research in the lab, Ms. Dziedzic earned her master’s degree in biotechnology from the Krieger School of Arts & Sciences at Johns Hopkins University in 2001. She continued to work with and manage the daily operations of Dr. Guilarte’s lab with a relocation to Columbia University in 2010 and then to FIU in 2016. Currently, Ms. Dziedzic is a Research Associate in the Department of Environmental Health Sciences and manages the research operations of Dr. Guilarte’s Brain, Behavior, and the Environment laboratory.
Research in the lab focuses on mechanism-based neurotoxicology and neuroscience using behavioral, cellular, and molecular approaches. Studies in the lab range from using primary cultures of neural and glial cells to the application of multiple brain imaging technologies. Main projects in the lab focus on exposures to heavy metals, specifically lead (Pb) and manganese (Mn), and their effects on the brain, as well as the validation and use of a biomarker of brain injury and inflammation, Translocator protein 18 kD (TSPO).
Lab
Ms. Dziedzic is the Lab Manager for Dean Guilarte’s Brain, Behavior, and the Environment laboratory.
Education
- Johns Hopkins University, MS
- Salisbury University, BS
Publications/Research
Full Publication List: https://www.ncbi.nlm.nih.gov/myncbi/1FaYefFhor-Ac/bibliography/public/
A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in Microglia.
Awake delta and theta-rhythmic hippocampal network modes during intermittent locomotor behaviors in the rat.
PET imaging of dopamine release in the frontal cortex of manganese-exposed non-human primates.
7,8-Dihydroxyflavone Rescues Lead-Induced Impairment of Vesicular Release: A Novel Therapeutic Approach for Lead Intoxicated Children. Zhang XL, McGlothan JL, Miry O, Stansfield KH, Loth MK, Stanton PK, Guilarte TR. (2018) Toxicological Sciences 161(1):186-195.
Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain. Cole TB, Coburn J, Dao K, Roqué P, Chang YC, Kalia V, Guilarte TR, Dziedzic J, and Costa LG. (2016) Toxicology 374:1-9.
Chronic early life lead (Pb2+) exposure alters presynaptic vesicle pools in hippocampal synapses. Guariglia SR, Stansfield KH, McGlothan J, Guilarte TR. (2016) BMC Pharmacology and Toxicology 17(1):56.
TSPO in a Murine Model of Sandhoff Disease: Presymptomatic marker of neurodegeneration and disease pathophysiology. Loth M, Choi J, McGlothan JL, Pletnikov MV, Pomper MG, and Guilarte TR. (2015) Neurobiology of Disease 85:174-186.
Novel BAC Mouse Model of Huntington’s Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype. Wegrzynowicz M, Jo Bichell T, Soares BD, Loth MK, McGlothan JL, Mori S, Alikhan FS, Hua K, Coughlin JM, Holt HK, Jetter CS, Pomper MG, Osmand AP, Guilarte TR, and Bowman AB. (2015) Journal of Huntingtons Disease 4(1):17-36.
Presynaptic mechanisms of lead neurotoxicity: effects on vesicular release, vesicle clustering and mitochondria number. Zhang XL, Guariglia SR, McGlothan JL, Stansfield KH, Stanton PK, and Guilarte TR. (2015) PLoS One 10(5):e0127461.
Early-life lead exposure recapitulates the selective loss of parvalbumin-positive GABAergic interneurons and subcortical dopamine system hyperactivity present in schizophrenia. Stansfield KH, Ruby KN, Soares BD, McGlothan JL, Liu X, and Guilarte TR. (2015) Translational Psychiatry 5:e522.
Sex differences in translocator protein 18 kDa (TSPO) in the heart: implications for imaging myocardial inflammation. Fairweather D, Coronado MJ, Garton AE, Dziedzic JL, Bucek A, Cooper LT Jr, Brandt JE, Alikhan FS, Wang H, Endres CJ, Choi J, Pomper MG, and Guilarte TR. (2014) Journal of Cardiovascular Translational Research 7(2):192-202.
Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition. Agusti A, Dziedzic JL, Hernandez-Rabaza V, Guilarte TR, and Felipo V. (2014) Metabolic Brain Disease 29(4):955-963.
Chronic exposure of mutant DISC1 mice to lead produces sex-dependent abnormalities consistent with schizophrenia and related mental disorders: a gene-environment interaction study. Abazyan B, Dziedzic J, Hua K, Abazyan S, Yang C, Mori S, Pletnikov MV, and Guilarte TR. (2014) Schizophrenia Bulletin 40(3):575-584.
Regional brain distribution of translocator protein using [(11)C]-DPA-713 PET in individuals infected with HIV. Coughlin JM, Wang Y, Ma S, Yue C, Kim PK, Adams AV, Roosa HV, Gage KL, Stathis M, Rais R, Rojas C, McGlothan JL, Watkins CC, Sacktor N, Guilarte TR, Zhou Y, Sawa A, Slusher BS, Caffo B, Kassiou M, Endres CJ, and Pomper MG. (2014) Journal of Neurovirology 20(3):219-232.
Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): Implications to manganese-induced parkinsonism. Guilarte TR, Burton NC, McGlothan JL, Verina T, Zhou Y, Alexander M, Pham L, Griswold M, Wong DF, Syversen T, and Schneider JS. (2008) Journal of Neurochemistry 107(5):1236-1247.
Developmental lead exposure impairs extinction of conditioned fear in young adult rats. McGlothan JL, Karcz-Kubicha M, Guilarte TR. (2008) Neurotoxicology 29(6):1127-1130.
Dysregulation of Glutamate Carboxypeptidase II in Psychiatric Disease. Guilarte TR, Hammoud DA, McGlothan JL, Caffo BS, Foss CA, Kozikowski AP, and Pomper MG. (2008) Schizophrenia Research 99(1-3):324-332.
VMAT-2 and dopamine neuron loss in a non-human primate model of Parkinson’s disease. Chen M-K, Kuwabara H, Zhou Y, Adams RJ, Brasic JR, McGlothan JL, Verina T, Burton NC, Alexander M, Kumar A, Wong DF, and Guilarte TR. (2008) Journal of Neurochemistry 105(2):78-90.
Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study. Guilarte TR, McGlothan JL, Degaonkar M, Chen MK, Barker PB, Syversen T, and Schneider JS. (2006) Toxicological Sciences 94(2):351-358.
Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Guilarte TR, Chen MK, McGlothan JL, Verina T, Wong DF, Zhou Y, Alexander M, Rohde CA, Syversen T, Decamp E, Koser AJ, Fritz S, Gonczi H, Anderson DW, and Schneider JS. (2006) Experimental Neurology 202(2):381-390.
Experience-dependent regulation of zif268 gene expression and spatial learning. Toscano CD, McGlothan JL, Guilarte TR. (2006) Experimental Neurology 200(1):209-215.
Acute manganese administration alters dopamine transporter levels in the non-human primate striatum. Chen MK, Lee JS, McGlothan JL, Furukawa E, Adams RJ, Alexander M, Wong DF, and Guilarte TR. (2006) Neurotoxicology 27(2):229-236.
Glutamate carboxypeptidase II levels in rodent brain using [125I]DCIT quantitative autoradiography. Guilarte TR, McGlothan JL, Foss CA, Zhou J, Heston WD, Kozikowski AP, and Pomper MG. (2005) Neuroscience Letters 387(3):141-144.
Methamphetamine-induced deficits of brain monoaminergic neuronal markers: distal axotomy or neuronal plasticity. Guilarte TR, Nihei MK, McGlothan JL, and Howard AS. (2003) Neuroscience 122(2):499-513.
Lead exposure alters cyclic-AMP response element binding protein phosphorylation and binding activity in the developing rat brain. Toscano CD, McGlothan JL, and Guilarte TR. (2003) Developmental Brain Research 145(2):219-228.
Selective decrease in NR1 subunit splice variant mRNA in the hippocampus of Pb2+-exposed rats: implications for synaptic targeting and cell surface expression of NMDAR complexes. Guilarte TR and McGlothan JL. (2003) Molecular Brain Research 113(1-2):37-43.
Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure. Guilarte TR, Toscano CD, McGlothan JL, and Weaver SA. (2003) Annals of Neurology 53(1):50-56.
Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain. Toscano CD, Hashemzadeh-Gargari H, McGlothan JL, and Guilarte TR. (2002) Developmental Brain Research 139(2):217-226.